Welcome to 9th meeting of the Invadosome Consortium

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  DAY1 October 1st

Session 1: Cellular Signaling Events Regulating Migration and Invasion.

12:00-16:00: Arrival and registration

16:00-16:15: Welcoming and Opening Remarks

16:15-17:00 Keynote Lecture: Dr. Stefan Linder (Universitätsklinikum Eppendorf): Eat up: podosomes in phagocytosis and endocytosis

17:00-17:20 Refreshment Break 

17:20-17:50 Dr. Gregory Fairn (Dalhousie University): Regulation of plasma membrane dynamics by phosphatidylinositol 3,4-bisphosphate

17:50-18:20 Dr. Claire Wells (King’s College London): Elucidating the functional role of p-21 activated kinase pathways in cancer cell invasion

18:20-18:50 Dr. Olivia Grafinger:  Cancer cell extravasation requires iplectin-mediated delivery of MT1-MMP at invadopodia

19:00 Welcome Dinner

 

DAY 2 October 2nd

Session 2: Cellular Signaling Events Regulating Migration and Invasion. Part 1.

08:00-0:900 Breakfast

09:00-9:30 Virtual/Remote. Dr. Philippe Chavrier (Institut Curie): Transcription Factor (TF)EB triggers a matrix degradation and invasion program of triple-negative breast cancer cells in response to mTORC1 repression

09:30-10:00 Dr. Stanley Stylli (The University of Melbourne): Targeting therapy induced invadopodia activity in glioblastoma 

10:00-10:15 SHORT TALK. Anouk Chatefau: SRC promotes tumor cell invasion by hijacking the translation machinery

10:15-10:30 SHORT TALK. Dr. Vicky Li: Integrin α6 isoforms mediate invadopodia formation and invasion of triple negative breast cancer cells.

10:30-11:00 Refreshment Break

11:00-11:30 Dr. Cheng-han Yu (University of Hong Kong): PI(3,4,5)P3-mediated Cdc42 activation regulates the assembly of macrophage podosome

11:30-12:00 Dr. Elisabeth Génot (Université de Bordeaux): The invasive endothelial tip cell in angiogenesis

12:00- 12:15 SPONSOR TALK- YEX

12:30-13:30 Lunch 

Session 3: Cellular Signaling Events Regulating Migration and Invasion. Part 2.

13:30-14:00 Dr. Olivier Destaing (Université Grenoble Alpes): Understanding and manipulating the multiple levels of dynamics into invadosomes

14:00-14:30 Dr. Takanari Inoue (John Hopkins): Synthetic control of actin polymerization, symmetry breaking and motility in active protocells

14:30-14:45 Erka Shata: Nck adaptor proteins regulate breast cancer cell invasion and metastasis

14:45-16:00 Lighting Talks for poster presenters (All Presenters)

16:00-17:30 Poster Session #1 (Refreshments provided)

17:30-18:00 Dr. Sergio Grinstein, University of Toronto: Gaining access to the surface of apoptotic cells for phagocytic removal

18:00-18:20 Dr. Ines Velazquez-Quesada: Sensory neuron-secreted CGRP inhibits the invasion of breast cancer cells

18:20- 18:40 Dr. Rosa Fontana: Targeting invadopodia to prevent cancer invasion and metastasis 

19:00-21:00 Meet the speaker (social hour)
 

DAY 3 October 3rd

Session 4: Imaging Technologies and Models to Monitor Cellular Dynamics. Part 1.

08:00-0:900 Breakfast

09:00-09:30 Dr. Peter Friedl (Radboud University): Connecting cancer metabolism, amoeboid dissemination and metastasis

09:30-10:00 Dr. Erik Sahai (Francis Crick Institute): Analysing cell dynamics at tumour/stroma boundaries

10:00-11:30 Poster Session #2 (Refreshments provided)

ACTIVITY  (Grouse Mountain) 11:30 to 17:30 (or free time)

Session 5: Imaging Technologies and Models to Monitor Cellular Dynamics. Part 2.

18:00-18:30 Dr. David Sherwood (Duke University: Fueling cell invasion with specialized mitochondria: dynamic and damaging

18:30-19:00 Dr. Sally Horne-Badovinac (University of Chicago): Initiation of rotational epithelial migration

19:00- 19:30 Virtual/Remote. Dr. Bojana Gligorijevic (Temple University): Cancer cells have the nerve to invade

19:30-21:00 Dinner
 

DAY 4 October 4th

Session 6: Chemical and Mechanical Signaling Regulating Migration and Invasion. Part 1.

08:00-0:900 Breakfast

09:00-09:30 Dr. Daniel Cohen (Princeton University): Cellular herding' to control cell migration and invasion

09:30-09:50 Dr Gabriel Kreider-Letterman: SPECTR Biosensors that report the stretch-mediated opening of specific talin domains; application to adhesion and podosome signaling 

09:50-10:05 Mariana Saraiva: Bacterial genotoxins trigger invadosome formation associated to matrix degradation

10:05-10:30 Refreshment break

10:30-11:00 Dr. Konstantinos Konstantopoulos (Johns Hopkins): The interplay of stiffness and confinement in cell migration

11:00-11:30 Dr. Ovijit Chaudhuri (Stanford University): Mechanics of collective invasion of the basement membrane 

11:30-11:45 Svetllana Kallogjerovic: The impact of ECM stiffness on sensory neurons in breast cancer

11:45-12:45 Science Communication Activity

12:45-14:00 Lunch
 

Session 7: Chemical and Mechanical Signaling Regulating Migration and Invasion. Part 2.

14:00-14:30 Dr. Jing Yang (UC San Diego): Regulation of epithelial-mesenchymal plasticity and tumor invasion by ECM stiffness

14:30-15:00 Dr. Vivek Shenoy (University of Pennsylvania): Modeling the recursive dialog between immune cells and the extracellular matrix

15:00-15:20 Dr. Aaron J. Farrugia: Fibrillar adhesions: A new paradigm

15:20-16:40 Student Awards and Prizes

16:40-17:00 Closing comments

17:00 Departure